张阳，男，汉族，中共党员，河北石家庄人。2020年博士毕业于重庆大学创新药物研究中心，其中，2017年9月-2020年5月在浙江大学进行联合培养。2020年9月入职5848vip威尼斯电子游戏药物化学教研室。主讲课程为《计算机辅助药物设计导论》与《药物化学》，研究方向为计算机辅助药物设计及人工智能。在研项目有：2021年度河北省教育厅青年拔尖人才项目，2021年度河北省自然科学基金优秀青年科学基金等，目前以第一作者，通讯作者共发表SCI论文11篇，其中中科院一区1篇，中科院二区8篇，中科院三区2篇。

科研业绩

(1)Geneticvariantrs7820258regulatestheexpression of indoleamine 2,3-dioxygenase 1 in brain regions. PNAS. doi: 10.1073/pnas.2007022117.

(2)The binding mode of vilazodone in the human serotonin transporter elucidated by ligand docking and molecular dynamics simulations. Phys Chem Chem Phys. 2020, 22(9):5132-5144. doi: 10.1039/c9cp05764a.

(3)Selective Inhibition of HDAC1 by Macrocyclic Polypeptide for the Treatment of Glioblastoma: A Binding Mechanistic Analysis Based on Molecular Dynamics. Front Mol Biosci. 2020, 7:41. doi: 10.3389/fmolb.2020.00041.

(4)Synthesis and Biological Evaluation of HDAC Inhibitors with a Novel Zinc Binding Group. Front Chem. doi: 10.3389/fchem.2020.00256.

(5)Exploring the Binding Mechanism of HDAC8 Selective Inhibitors: Lessons from the Modification of Cap Group. doi: 10.1002/jcb.29583. J Cell Biochem. 2020;1–11. doi: 10.1002/jcb.29583.

(6)Synthesis of Chalcone Derivatives: Inducing Apoptosis of HepG2 Cells via Regulating Reactive Oxygen Species and Mitochondrial Pathway. Front Pharmacol, 2019. 10: p. 1341. doi: 10.3389/fphar.2019.01341. 

(7)How Does Chirality Determine the Selective Inhibition of Histone Deacetylase 6? A Lesson from Trichostatin A Enantiomers Based on Molecular Dynamics. ACS Chem Neurosci. 2019, 10, 5, 2467–2480. doi: 10.1021/acschemneuro.8b00729.

(8)Genome-wide expression profiling of glioblastoma using a large combined cohort. Sci Rep, 2018. 8 (1): p. 15104. doi: 10.1038/s41598-018-33323-z.

(9)Comparison of the Inhibitory Binding Modes Between the Planar Fascaplysin and Its Nonplanar Tetrahydro-β-carboline Analogs in CDK4. Front Chem. doi: 10.3389/fchem.2021.614154.

(10)Discovery of Potent EGFR Inhibitors With 6-Arylureido-4-anilinoquinazoline Derivatives. Front Pharmacol. doi: 10.3389/fphar.2021.647591.

(11)Individual Variability in Human Urinary Metabolites Identifies Age related, Body Mass Index related, and Sex related Biomarkers. Mol Genet Genomic Med. doi: 10.1002/mgg3.1738.