天然药物化学专业研究生阅读700篇文献

  一．       提取、分离、分析方法

1.1  High Capacity Countercurrent Chromatography for Fast Isolation of Natural Products

1.2 An Overview of HPTLC-A Modern Analytical Technique with Excellent Potential for Automation, Optimization, Hyphenation, and Multidimensional Applications

1.3  High Performance Liquid Chromatographic Separation Methods

1.4  HPLC in Natural Product Analysis- The Detection Issue

1.5  CCC-Recent applications of counter-current chromatography to the isolation of bioactive natural products

1.6  Advances in Techniques for Profiling Crude Extracts and for the Rapid Identification

1.7  High Performance Liquid Chromatographic Separation Methods

1.8  Supercritical fluid extraction in herbal and natural product studies - a practical review

1.9  Applications of analytical high-speed counter-current chromatoraphy in natural products chemistry

1.10  Isolation of Microbial Natural Products

1.11  Role of advances in chromatographic techniques in phytochemistry

1.12  Natural product isolation

1.13  Role of advances in chromatographic techniques in phytochemistry

1.14  Planar Chromatography

1.15  The state of the art in thin-layer chromatography–mass spectrometry- a critical appraisal

1.16  Thin-layer chromatography in food and agricultural analysis

1.17  Planar chromatography at the turn of the century      

1.18  The bridge between TLC and HPLC: overpressured layer chromatography (OPLC)

1.19  High-resolution thin-layer chromatography of gangliosides

1.20  Chiral separations using the macrocyclic antibiotics: a review 

1.21  Soxhlet extraction of solid materials: an outdated technique with a promising innovative future 

二．  结构鉴定方法

2.1 DFT molecular modeling and NMR conformational analysis of a new longipinenetriolone diester

2.2  NMR-spectroscop- analysis of mixtures- From structure to function

2.3 Advantages-and-disadva Advantages and disadvantages of nuclear magnetic resonance

2.4  Application of MS and NMR to the structure elucidation of complex sugar moieties of natural products

2.5  NMR Elucidation of organic compounds from natural sources using 1D and 2D NMR

2.6  The role of solvents in the signal separation for quantitative 1H NMR

2.7  Chasing Molecules That Were Never There-Structure Elucidation and Revise

2.8  Survey of marine natural product structure revisions- A synergy of spectroscopy and chemical synthesis

2.9  Spectroscopic Methods of Steroid Analysis

2.10  Determination of Absolute Configuration of Natural Products

2.11  From Relative to Absolute Configuration of Complex Natural Products

2.12  Advanced NMR Approaches for a Detailed Structure Analysis of Natural Products

2.13 Application of liquid chromatography–nuclear magnetic resonance spectroscopy to the identification of natural products

2.14  Applications of Modern Mass Spectrometry Techniques in Natural Products Chemistry

2.15  The Assignment of Absolute Configuration by NMR

2.16  NMR – Small Molecules and Analysis of Complex

2.17  Determination of Structure including Absolute Configuration of Bioactive Natural Products

2.18  Mass Spectrometry-An Essential Tool for Trace Identification and Quantification

2.19  Applications of Modern Mass Spectrometry Techniques in Natural Products Chemistry

2.20  Mass Spectrometry as a Powerful Analytical Technique for the Structural Characterization of Synthesized and Natural Products

2.21  Structure elucidation of organic compounds from natural sources using 1D and 2D NMR techniques

2.22  Quantitative two-dimensional HSQC experiment for high magnetic field NMR

2.23  The role of solvents in the signal separation for quantitative 1H NMR

2.24  Application of MS and NMR to the structure elucidation of complex sugar moieties of natural products- exemplified by the steroidal saponin from Yucca filamentosa L.

2.25  J-Based Analysis and DFT–NMR Assignments of Natural Complex Molecules

2.26  New methods for stereochemical determination of complex polyketides

2.27  Extending the Scope of NMR Spectroscopy with with new probe

2.28  Advantages and disadvantages of nuclear magnetic resonance spectroscopy as a hyphenated technique

2.29  New methods for stereochemical determination of complex polyketides

2.30  NMR Spectroscopy of Natural Substances

2.31  Advances of high-resolution NMR techniques in the structural and metabolic analysis of plant biochemistry

2.32  Integrated approaches to the configurational assignment of marine natural Products

2.33  The development of strategies for terpenoid structure determination of terpene

2.34  Circular dichroism, a powerful tool for the assessment of absolute configuration of flavonoids

2.35  Determination of Absolute Configuration of Natural Products-Theoretical Calculation of Electronic Circular Dichroism as a Tool

2.36  From Relative to Absolute Configuration of Complex Natural Products-Interplay Between NMR, ECD, VCD, and ORD Assisted by ab initio Calculations

2.37  Milestones in the first fifty years of NMR

2.38  A  DMSO-Compatible Orienting Medium-Towards the Investigation of the Stereochemistry of Natural Products

2.39  Microscale methodology for structure elucidation of natural

2.40  Extending the Scope of NMR Spectroscopy with Microcoil Probes

2.41  NMR Determination of the Bioactive Conformation of Peloruside A Bound To Microtubules

2.42  Natural Product Analysis over the Last Decades

2.43  New Chemical Constituents of Euphorbia quinquecostata and Absolute Configuration Assignment by a Convenient Mosher Ester Procedure Carried Out in NMR Tubes

2.44  NMR Chemical Shifts of Common Laboratory Solvents as Trace Impurities

三．天然药物化学历史

3.1 A  Brief History of Natural Products Chemistry

3.2 天然药物化学发展的历史性变迁

3.3 中国植物化学的回顾与展望 

3.4  A  natural history of botanical therapeutics 

3.5  Woodward Quinine 

3.6  The First Synthetic Drugs and their Analogues

四．生物碱

4.1  Structural diversity and defensive properties of diterpenoid alkaloids

4.2  Plant Alkaloids

4.3  Alkaloids in the human food chain – Natural occurrence and possible adverse effects

4.4  Alkaloids, Pharmaceutical Analysis of

4.5  Alkaloids

4.6  The potential of alkaloids in drug discovery

4.7  Alkaloid Drugs

4.8  Attract and deter-a dual role for pyrrolizidine alkaloids

4.9  Bioactive Alkaloids from the Sea- A Review

4.10  Bioactive Heterocyclic Alkaloids of Marine Origin

4.11  Bioactive Marine Alkaloids

4.12  C 20-diterpenoid alkaloids  

4.13  Camptothecin, over four decades of surprising findings

4.14  Camptothecin-Therapeutic potential and biotechnology

4.15  Opium poppy- blueprint for an alkaloid factory

4.16  Pandanus Alkaloids- Chemistry and Biology

4.17  The Vinca Alkaloids

4.18  Tropane alkaloids- old drugs used in modern medicine  Original

4.19  Daphniphyllum alkaloids-Structures, Biogenesis, and Activities

4.20  New Trends in Alkaloid Isolation and Structure Elucidation

4.21  Bioactive Alkaloids-Structure and Biology

4.22  Camptothecin and Analogs-Structure and Synthetic Efforts

4.23  Alkaloids

4.24  Recent progress in the chemistry of the Stemona alkaloids

4.25  Structural diversity and defensive properties of diterpenoid alkaloids

4.26  Evolution and current status of the phytochemistry of nitrogenous compounds

4.27  Diterpenoid alkaloids

五．黄酮

5.1. Flavonoids as chemosystematic markers in the tribe Cichorieae of the Asteraceaeq

5.2 Spiroflavonoid compounds- Structure and distribution in nature review  

5.3  The Biosynthesis of Flavonoids 

5.4  Progress in the Research on Naturally Occurring Flavones and Flavonols

5.5  Extraction, separation, and detection methods for Phenoic and flaonoids

5.6  Flavanols-digestion, absorption and bioactivity

5.7  Identification of natural epimeric flavanone glycosides by NMR spectroscopy

5.8  Isoflavonoids-Biochemistry

5.9  A predictive tool for assessing 13C   NMR chemical shifts of flavonoids

5.10 Analysis of flavonoids- Tandem mass spectrometry, computational methods, and NMR  

5.11  Cancer phytotherapeutics- role for flavonoids at the cellular level 

5.12  Cardiovascular Ion Channels as a Molecular Target of Flavonoids

5.13  Flavonoids- Diet and Health Relationships

5.14  Flavonoids- Promising anticancer agents

5.15  Isoflavones as Apoptosis Inducers in Human Hepatoma HuH-7 Cells

5.16  Mass spectrometry in the structural analysis of flavonoids

5.17  The flavonoid biosynthetic pathway in plants- Function and evolution

5.18  Anti- and Pro-oxidant of Flavonoids

5.19  Anti-flammatory

5.20  Natural Flavonoids as multifunctional agents in prevention of diabetic cataract

5.21  Phytochemistry of  Flavonoids

5.22  Isolation and Identification of Flavonoids

5.23  The Stereochemistry of Flavonoids

5.24  Advances in flavonoid research since 1992

5.25  Cancer preventive effects of flavonoids-a review

5.26  Flavonoids and isoflavonoids – a gold mine for metabolic engineering

5.27  Flavonoids- Old and new aspects of a class of natural therapeutic drugs

5.28  Mass spectrometric methods for the determination of flavonoids in biological samples

5.29  Overview of methods for analysis and identification of flavonoids

5.30  Structure–activity relationships of flavonoid-induced cytotoxicity on human leukemia cells

5.31  The biochemistry and medical significance of the flavonoids

5.32  Chemistry of Flavonoid-Based Colors in Plants

5.33  Isoflavonoids-Biochemistry, Molecular Biology, and Biological Functions

5.34  Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines

5.35  Identification of natural epimeric flavanone glycosides by NMR spectroscopy

5.36  Progress in the Research on Naturally Occurring Flavones and Flavonols-An Overview

5.37 Significance of Flavonoids in Plant Resistance 

5.38  Advances in Application of High-Speed Countercurrent Chromatography in Separation and Purification of Flavonoids

5.39  Complete 13C and 1H NMR spectralof isoflavonoids

5.40  Flavanols and Anthocyanins in Cardiovascular Health- A Review of Current Evidenc

5.41  Flavonoid–drug interactions-Effects of flavonoids on ABC transporters

5.42  Flavonoid–insect interactions-recent advances in our knowledge

5.43  Structure-Activity Requirements for Flavone Cytotoxicity and Binding to Tubulin

5.44  Flavonoids and their glycosides, including anthocyanins

5.45  Flavonoids- New roles for old molecules

5.46  Flavonoids-a re-run of the carotenoids story?

5.47  Flavonoids, Old and new aspects of a class of natural therapeutic drugs

5.48  Furanoflavonoids- an overview

5.49  Genistein

5.50  Neoflavones-Natural distribution and spectral and biological properties

5.51  Phytoestrogen-A Review

5.52  Recent advances in betalain research

5.53  Structure–radical scavenging activity relationships of flavonoids

5.54  Xanthohumol and related prenylflavonoids from hops and

5.55  Role of phenolics in plant evolution

5.56  Xanthones in Hypericum

六．  倍半萜

6.1  Sesquiterpenoids from Lactuca tatarica

6.2 A new -methylene--lactone sesquiterpene from Hedyosmum arborescens 

6.3  Terpenoids from the seeds of Artemisia annua 

6.4 Sesquiterpenes- Natural products that decrease cancer growth  

6.5  Sesquiterpenes

6.7  13C NMR spectroscopy of eudesmane sesquiterpenes

6.8  Guaianolides in apiaceae perspectives on pharmacology and Biosynthesis

6.9  Sesquiterpene lactones and their precursors as chemosystematic markers

6.10  Sesquiterpenes- Natural products that decrease cancer growth

6.11  Eudesmane sesquiterpenoids from the Asteraceae family  Jia ZJ

6.12  Isolation, Chemical, and Biotransformation Routes of Labdane-type Diterpenes

6.13  Quadrane sesquiterpenes-Natural sources, biology, and syntheses

6.14  13C NMR Spectra of Natural Products-Guaianolides

6.15  Occurrence, biological activity and synthesis of drimane sesquiterpenoids

6.16  Anti-Cancer Potential of Sesquiterpene Lactones- Bioactivity and Molecular Mechanisms  

6.17 Artemisinin, Promising Lead Natural Product for Various Drug Development  

6.18  13C NMR spectroscopy of eudesmane sesquiterpenes 

6.19  Enzymatic Formation of Sesquiterpenes

6.20  Quantitative structure–activity relationship of sesquiterpene lactones with cytotoxic activity

6.21  Sesquiterpenoids

6.22  Sesquiterpene lactones and their precursors as chemosystematic markers in the tribe Cichorieae of the Asteraceae

6.23  Sesquiterpenes-Natural Products That Decrease Cancer Growth

6.24  What made sesquiterpene lactones reach clicnic tral

6.25  Guaianolides in apiaceae perspectives on pharmacology and biosynthesis

6.26  Natural disesquiterpenoids

6.27  The Daucane (Carotane) class of sesquiterpenoids

6.28  Sesquiterpene lactones as chemotaxonomic markers in genus Anthemis

6.29  Chemistry, Biosynthesis and Biological Activity of Artemisinin and Related Natural Peroxides

6.30  Sesquiterpene coumarins

6.31  Structure-activity relationships of sesquiterpene lactones

七．二萜

7.1  Isolation, Chemical, and Biotransformation Routes of Labdane-type Diterpenes

7.2  Diterpenes

7.3  Occurrence, biological activities and synthesis of kaurane diterpenes and their glycosides

7.4  Diterpenoids from Isodon species and their biological activities Sun HD-Review

7.5  Labdanes of Natural Origin-Biological Activities

7.6  Two rings in them all-The labdane-related diterpenoids

7.7  Structure, biosynthetic relationships and chemical synthesis of the icetexane diterpenoids

7.8  Clerodane Diterpenoids

7.9  Gibberellins

7.10  Steviosied

7.11  Stevioside and related compounds- Therapeutic benefits beyond sweetness

7.12  Stevioside and related compounds - Molecules of pharmaceutical promise- A critical overview

7.13  The Trachylobane Diterpenes

7.14  Ent-Kaurane diterpene-Isolation, Properties, and Chemical Transformations

7.15  Jatropha diterpenoids-a Review

7.16  Neo-Clerodane diterpenoids from Ajuga-structural elucidation and biological activity

7.17  Labdanes of Natural Origin-Biological Activities (1981-2004)

7.18  Occurrence, Biological Activities and Synthesis of Kaurane Diterpenes and their Glycosides

7.19  Natural Taxanes Developments Since 1828

7.20  Constituents from Salvia Species and Their Biological Activities

7.21  Terpene trilactones from Gingko biloba-From ancient times to the 21st century  

7.22  Stevioside and related compounds: Therapeutic bene fits beyond sweetness

八．       三萜

8.1    Meliaceous Limonoids- Chemistry and Biological Activities

8.2  Triterpenes

8.3  On the origins of triterpenoid skeletal diversity

8.4  Triterpene-based plant defenses

8.5  Biological activities and chemistry of saponins from Panax ginseng

8.6  Sea cucumbers triterpene glycosides, the recent progress in structural

8.7  The formation of sugar chains in triterpenoid saponins and glycoalkaloids

8.8  Naturally Occurring Triterpenoid Saponins

8.9  Molecular activities, biosynthesis and evolution of triterpenoid saponins

8.10  Ursolic acid- An anti- and pro-inflammatory triterpenoid

8.11  Biological Activity and Pharmacological Prospects of Lupane terpene

8.12  Triterpene-based plant defenses

8.13  Effects of triterpenes on the immune system

8.14  Ginsenosides- Chemistry, Biosynthesis, Analysis, and Potential Health Effects

8.15  Oleanolic acid

8.16  Boswellic acids

8.17   Unusually cyclized triterpenes occurrence, biosynthesis and chemical synthesis

8.18  Lupeol- Connotations for chemoprevention

8.19  A convenient separation of ursolic and oleanolic acid  

8.20  Pharmacological activities of natural triterpenoids and their therapeutic implications

8.21  Triterpenoids from the Schisandraceae family

8.22  Azadirachtin, a scientific gold mine

九．  甾体皂苷

9.1  Withanolides and Related Steroids

9.2  Spectroscopic Methods of Steroid Analysis

9.3  NMR spectroscopy of steroidal sapogenins and steroidal saponins

9.4  Sterol and Steroid Biosynthesis and Metabolism in Plants and Microorganisms

9.5  Saponins

9.6  Saponins as cytotoxic agents

9.7  Saponins, classification and occurrence in the plant kingdom

9.8  Structural elucidation of saponins

9.9  The nutritional & biological significance of saponins

9.10  Biological activities and distribution of plant saponins

9.11  Chemical study and medical application of saponins as anti-cancer agents

9.12  Biochemistry of Sterol

9.13  Phytoecdysteroids-Diversity, Biosynthesis and Distribution

9.14  Plant sterols- biosynthesis, biological and their importance to human nutrition

9.15  Four Novel Withanolide-Type Steroids from the Leaves of Solanum cilistum

9.16  Chromatographic determination of plant saponins

9.17  Pharmacological properties of plant sterols In vivo and in vitro observations  

十． 木脂素

10.1  Biomimetic Synthesis of Natural Lignan

10.2  The Naturally Occurring Lignans

10.3  Lignans, Biosynthesis and Function

10.4  Lignans (Neolignans) and AllylPropenyl Phenols-Biogenesis, Structural Biology, and BiologicalHuman Health

10.5  An historical perspective on lignan biosynthesis

10.6  Biological activities of lignans and stilbenoids associated with plant-insect

10.7  Lignans and neolignans as lead compounds

10.8  Lignans in plant cell and organ cultures

10.9  Lignans in treatment of cancer and other diseases

10.10  Characterization of lignin by 1H and 13C NMR spectroscopy

10.11  Dietary lignans- physiology and potential for cardiovascular

10.12  Lignins- Major Sources, Structure and Properties

10.13  Recent advances in the chemistry of lignans

10.14  Recent developments in lignin chemistry

10.15  Some Aspects of the Chemistry of Lignans

10.16  The chemistry of the lignan group of natural products

10.17  13C NMR Spectroscopy of Lignan and Neolignan Derivatives

10.18  An update on bioactive plant lignans

10.19  Chemoinduction of cytotoxic selectivity in Podophyllotoxin-related lignans

10.20  Progress on the Chemistry of Dibenzocyclooctadiene Lignans

十一．挥发油

11.1  Biological properties of essential oils- An updated review

11.2  Biological and pharmacological activities of carvacrol and carvacrol bearing essential oils

11.3  Chemistry and Bioactivity of Essential Oils

11.4  Chemistry of Essential Oils

11.5  Ecological Roles of Vegetative Terpene Volatiles

11.6  Essential Oil Drugs - Terpene Composition of Aromatic Herbs

11.7  Volatile sesquiterpenes from fungi- what are they good for

11.8  Bioactivity of Essential Oils and Their Components

11.9  Essential oils in agriculture, industry and consumer products

11.10  Plant volatiles Production, function and pharmacology

11.11  Plant Volatiles in Defence

11.12  Volatiles for the Perfume Industry

11.13  Hop Essential Oil- Analysis, Chemical Composition and Odor Characteristics

11.14  Flavors and Fragrances

11.15  Secondary Metabolites- Attracting Pollinators

十二．鞣质

12.1  Ellagitannins – nature, occurrence and dietary

12.2 Tannins- Current knowledge of food sources, intake bioavailability and biological effects

12.3  Condensed vegetable tannins-Biodiversity in structure and biological activities

12.4  Natural Polyphenols (Vegetable Tannins) as Drugs Possible Modes of Action

12.5  Systematics and health effects of chemically distinct tannins in medicinal plants

12.6  New methods for analysis of Tannin

12.7  Tannins and related polyphenols Perspectives on their chemistry, biology, ecological effects, and human health protection

12.8  Tannins and Tannin Agents

12.9  Vegetable tannins-Lessons of a phytochemical lifetime

12.10  Analysis of hydrolable Tannines

十三．香豆素

13.1  Natural coumarins- Methods of isolation and analysis

13.2  Sesquiterpene coumarins

13.3  The chemistry and biology of bicoumarins

13.4  13C -NMR spectroscopy of coumarins and their derivatives- A comprehensive review

13.5  Biosynthesis of Coumarins

13.6  Biosynthesis of Coumarins

13.7  Natural coumarins- Methods of isolation and analysis METHODS OF ANALYSIS AND PROCESS CONTROL

13.8  Biosynthesis of Coumarins

十四．  醌类

14.1  Biological activity of quinones

14.2  The Chemistry and Biology of Alkannin, Shikonin, and Related Naphthazarin Natural Products

14.3  Quinone-Recent Advances in Chemistry, Biology and Biotechnology of Alkannins

14.4   9,10-Anthraquinones and Other Biologically Active Compounds

14.5  Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents

14.6  Occurrence, biosynthesis and function of isoprenoid quinones

14.7  Quinone-Recent Advances in Chemistry, Biology and Biotechnology of Alkannins

14.8  The chemical and biological activities of quinones

14.9  Natural Terphenyls Developments since 1877  LiuJiKai CR

14.10  Pigments of fungi

十五．  海洋天产物

15.1   Marine Natural product chemistry

15.2   Natural Products Drug Discovery

15.3    Marine natural products and their potential applications as anti-infective agents

15.4  Marine Natural Products Chemistry- Past, Present, and Future

15.5  Marine-Past Present and future

15.6  Marine Drugs-Implication and Future Studies

15.7  Marine Natural Products and Marine Chemical Ecology

15.8  Quality not Quantity- The Role of Marine Natural Products in Drug Discovery and Reverse Chemical Proteomics

15.9  Bioactive Sesterterpenes and Triterpenes from Marine Sponges- Occurrence and Pharmacological Significance

15.10  When two steroids are better than one-The dimeric steroid-pyrazine marine alkaloids

15.11 Terpenoids from marine organisms unique structures and their pharmacological potential

15.12  Marine Natural Products-Chemical Diversity

15.13  Bioactive marine sesterterpenoids

15.14  Bioactive Sesterterpenes and Triterpenes from Marine Sponges- Occurrence and Pharmacological Significance

15.15  Biologically active triterpene glycosides from sea cucumbers

15.16  Steroids from sponges Recent reports

15.17  Marine polyether triterpenes

15.18  Producing drugs from marine sponges

15.19  Marine Toxins-An Overview

15.20  Marine Natural Products and Related Compounds in Clinical and Advanced Preclinical Trials

15.21  Bioactive natural products from marine cyanobacteria for drug discovery

15.22  Highlight Marine Natural products

15.23  The Oceans and Human Health-The Discovery and Development of Marine-Derived Drugs

15.24  Bioactive Metabolites of Marine Algae, Fungi and Bacteria

15.25  Bioactive Marine Alkaloids

15.26  Marine natural products

十六．  新药开发

16.1  Drug Discovery and Natural Products- End of an Era or an Endless Frontier？

16.2 基于经典天然产物的药物发现研究

16.3  Drug discovery from medicinal plants

16.4  Natural Products as Leads to Potential Drugs-An Old Process or the New Hope for Drug

16.5  The Renaissance of Natural Product as  Drug cadidates

16.6  The Role of Natural Product Chemistry in Drug Discovery

16.7  The Value of Plants Used in Traditional Medicine for Drug Discovery

16.8  Natural Products from Marine Invertebrates and Microbes as Modulators

16.9  The Chemical Diversity of Bioactive Molecules and Therapeutic Potential of Medicinal Plants

16.10  Natural products and Pharma 2011- Strategic changes spur new opportunities

16.11  Natural Products Drug Discovery

16.12 A review of high throughput technology for the screening of natural products

16.13  Biodiversity and drug discovery - a symbiotic relationship

16.14  Natural Products as a Robust Source of New Drugs and Drug Leads- Past Successes and Present Day Issues

16.15  Natural products in drug discovery

16.16  Natural products-An evolving role in future drug discovery

16.17  Unexpected applications of secondary metabolites

16.18  Natural Products in Drug Discovery

16.19  Impact of Natural Products on Developing New Anti-Cancer Agents

16.20  Plant-derived natural products as leads for drug discovery

16.21  Natural Products as Leads to Potential Drugs-An Old Process or the New Hope for Drug discovery

16.22  Plants as a source of anti-cancer agents-1

16.23  The impact of natural products upon modern drug discovery

16.24  Trends in natural product-based drug discovery,

16.25  The influence of natural products upon drug discovery

16.26  Biodiversity and drug discovery - a symbiotic relationship

16.27  Cancer- Are herbal medicines ripe for the cancer clinic

16.28  Drug Discovery and Development

16.29  Challenges and opportunities in drug discovery from Plants

16.30  Drugs from the Sea - Opportunities and Obstacles

16.31  Natural Products Drug Discovery

16.32  Natural Products in Drug Discovery - Concepts and Approaches for Tracking Bioactivity

16.33  Natural products in drug discovery – Creating a new vision

16.34  Natural products to drugs-natural product-derived compounds in clinic trial

16.35  从草乌化学研究开发的新药思考中药现代化的方法

16.36   Natural products as leads to anticancer drugs

16.37 The continuing search for antitumor agents from higher plants

16.38  The evolving role of natural products in drug discovery

16.39  The future of metabolic phytochemistry- Larger numbers of metabolites, higher resolution, greater understanding

16.40  The Role of Pharmacognosy in Modern Medicine and Pharmacy

16.41  Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

16.42  Natural Products As Sources for New Pesticides

16.43  Natural Products and Traditional Medicine Turning on a Paradigm

16.44 Drug-like Properties- Guiding Principles for the Design of Natural Product Libraries

16.45  Analysis and Purification of Bioactive Natural Products-The AnaPurNa Study

16.46  Natural products as a source of Alzheimer’s drug leads

16.47  Marine Pharmcy-Past, present and furter

16.48  Chemical ecology of the marine plankton

16.49  Strategies for discovering drugs from previously unexplored natural products

16.50  Novel drugs from botanical sources

16.51  Medicines from nature: are natural products still relevant to drug discovery?

16.52  Natural and synthetic substances related to human health  

16.53  Natural products from around the world

十七．综 述

17.1  Terpenoid biomaterials

17.2  Revisited after 50 Years- The `Stereochemical Interpretation of the Biogenetic Isoprene Rule for the Triterpenes'

17.3  Naturally occurring dimers from chemical perspective

17.4  Natural Products in Plants- Chemical Diversity

17.5  Natural products and combinatorial chemistry- back to the future

17.6  Role of Natural Products in Nature- Plant-Insect Interactions

17.7  Secondary Metabolism

17.8  Natural products – a simple model to explain chemical diversity

17.9  Synthesis-Guided Structure Revision of the Sarcodonin, Sarcoviolin, and Hydnellin Natural Product Family

17.10  Introduction to the Different NP

17.11  Why-are-secondary-metabolites-(natural-products)-biosynthesized

17.12  Plant Polyphenols Chemical Properties, Biological Activities, and Synthesis

17.13  Azadirachtin, a scientific gold mine

17.14  Biodiversity-Our greatest natural resource

17.15  Glycoside vs. Aglycon- The Role of Glycosidic Residue in Biological Activity

17.16  Inedible Mushrooms-A Good Source of Biologically Active Substances

17.17  Nature knows best-An amazing reaction cascade is uncovered by design and discovery

17.18  Natural Products as Chemical Probes

17.19  Natural Products as Tools for Neuroscience-Discovery and Development of Novel Agents to Treat Drug Abuse

17.20  Natural Products as Molecular Messengers

17.21  Secondary Metabolites-Attracting Pollinators

17.22  Why do Plants Produce Drugs- Which is their Function in the Plants

17.23  Natural products as probes of cell biology

17.24  Natural products in cancer chemotherapy past, present and future

17.25  Lessons from natural molecules

17.26  Rediscovery of known natural compounds-Nuisance or goldmine

17.27  Terpenoids As Therapeutic Drugs and Pharmaceutical Agents

17.28  Natural Products as Sweeteners and Sweetness Modifiers

17.29  Biosynthesis and Emission of Isoprene, Methylbutanol and Other Volatile Plant Isoprenoids

17.30  Natural Products in Plants- Chemical Diversity

17.31  Plant Terpenoids

17.32  Plant-Derived Natural Products Research- Recent Progress in Drug Discovery

17.33  Plant-Microbe Interactions and Secondary Metabolites with Antibacterial, Antifungal and Antiviral Properties

17.34  Poisons of Plant Origin

17.35  The Mevalonate and Methylerythritol Phosphate Pathways-Terpenoids and Steroids

17.36  Terpenoids in Plant Signaling-Chemical Ecology

17.37  Chemical feature of med Plant

17.38  Review of the methods used for isolating pharmaceutical lead compounds from traditional medicinal plants

17.39  Highly Sweet Compounds of Plant Origin

17.40  Terpene and bread cancer chemoprevention

17.41  Natural products - The future scaffolds for novel antibiotics

17.42  Twenty-five years of chemical ecology

17.43  Phytochemicals The good, the bad and the ugly?

17.44  Antimalarials from nature

17.45  Biologically Active Proteins from Natural Product Extracts

17.46  Metabolome diversity-too few genes, too many metabolites

17.47  Structural revisions of natural products by Computer-Assisted Structure

17.48  Biogenesis, molecular regulation and function of plant isoprenoids

17.49  Monoterpene and sesquiterpene synthases and the origin of terpene skeletal diversity in plants

17.50  Chemopreventive and therapeutic effects of curcumin

17.51  Curcumin-The story so far

17.52  Curcumin From ancient medicine to current clinical trials

17.53  From Natural Products to Bioorganic Chemistry. What’s Next

17.54  Natural products for cancer prevention a global perspective

17.55  Natural products-An evolving role in future drug discovery

17.56  Meliaceous Limonoids Chemistry and Biological Activities-Limonoids

17.57  Natural products in cancer chemotherapy- past, present and future

17.58  Isolation, Chemical, and Biotransformation Routes of Labdane-type Diterpenes

17.59  Antimalarials from nature

17.60  The Value of Plants Used in Traditional Medicine for Drug Discovery

17.61  Endophytes- a rich source of functional metabolites

17.62  Antibacterial Natural Products in Medicinal Chemistry-Exodus or Revival?

17.63   A  brief tour of myxobacterial secondary metabolism

17.64  Fostriecin- Chemistry and Biology

17.65  Natural products from semi-mangrove flora- source, chemistry and bioactivities

17.66  One pathway, many products

17.67  Role of Natural Products in Nature-Plant–Insect Interactions

17.68  Plant Orthoesters

17.69  The function of terpene natural products in the natural world

17.70  Nuclear Magnetic Resonance Spectroscopic Approaches for the Determination of Interglycosidic Linkage and Sequence in Oligosaccharides?

17.71  Insect Antifeedants- A review

17.72  Empirical antibacterial drug discovery-Foundation in natural products

17.73  Allelochemicals

17.74  Insects and their chemical weaponry: New potential for drug discovery

17.75  Current methodologies for the analysis of aminoglycosides

17.76  Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis

17.77  What can a chemist learn from nature’s macrocycles? – A brief, conceptual view

17.78  Will natural products remain an important source of drug research for the future?

17.79  The comparative biochemistry of phytoalexin induction in plants

17.80  Bioorganic Chemistry of Ceramid

17.81  Plant latex and other exudates as plant defense systems: Roles of various defense chemicals and proteins contained therein

17.82  The Marvels of Biosynthesis-Tracking Nature's Pathways

十八．全合成

18.1 Natural products synthesis- Enabling tools to penetrate natures secrets of bioqenesis and biomechanism

18.2  Modern synthetic efforts toward biologically active terpenes

18.3  Inspirations, Discoveries, and Future Perspectives in Total Synthesis

18.4  From nature to the laboratory and into the clinic

18.5  Inspirations, discoveries, and future perspectives in total synthesis

18.6  Small Molecule Natural Products in the Discovery of Therapeutic

18.7  The Art and Science of Organic and Natural Products Synthesis

18.8  The Art and Science of Total Synthesis at the Dawn of the Twenty-First Century

18.9  From Natural Products to Medicinal Chemistry

18.10  Chemical Synthesis in Structure correction

18.11  Chasing Molecules ThatWere Never There Misassigned-Chemical Synthesis in Structure correction

18.12  Joys of Molecules. 1. Campaigns in Total Synthesis

18.13  Joys of Molecules. 2. Endeavors in Chemical Biology and Medicinal Chemistry

18.14  Modern synthetic efforts toward biologically active terpenes

18.15  Total Syntheses of Colchicine in Comparison A Journey through 50 Years of Synthetic Organic Chemistry

18.16  The Art of Total Synthesis

18.17  Natural products as an inspiration in the diversity-oriented synthesis bioactive compound libraries

18.18  Reserpine- A Challenge for Total Synthesis of Natural Products

18.19  Studies toward the Total Synthesis of Nominine

18.20  Total Synthesis of Oxacyclic Macrodiolide Natural Products

18.21  Total Synthesis of Marine Polycyclic Ethers  

十九．结构修饰

19.1 The chemistry of zerumbone. Part 5 Structural transformation of

19.2 Acid Cyclization of 5-Ketogermacren-6,12-olides. A Reactivity and Conformational Study

19.3  Appendino G-Unnatural natur products OL

19.4  Transition-Metal-Catalyzed Group Transfer Reactions for Selective C-H Bond Functionalization of Artemisinin

19.5  Interesting transformations of naturally occurring cassane diterpenoids and bioevaluation of the products

19.6  Deletion of the Oxetane Ring in Docetaxel Analogues-Synthesis and Biological Evaluation

19.7  Synthesis, Activity, and Molecular Modeling Studies of Novel Human Aldose Reductase Inhibitors Based on a Marine Natural Product

二十． 经典教材章节

20.1  Plant secondary metabolites.Targets and mechanisms of allelopathy

20.2  Terpenoids (Isoprenoids)

20.3  Terpenoids As Therapeutic Drugs and Pharmaceutical Agents

20.4  The Chemical Diversity of Bioactive Molecules and Therapeutic Potential of Medicinal Plants

20.5  The Role of Phenols in Plant Defense

20.6  The Use of Plant Cell Biotechnology for the Production of Phytochemicals

20.7  Secondary Metabolism

20.8  Terpenoids As Therapeutic Drugs and Pharmaceutical Agents

20.9  The Building Block for Natural Products in Plant

20.10  Biochemistry Of terpenoids

20-11  The acetate pathway

20-12  The Shikimate pathway

20-13  The mevalonate and dexyxylulose phosphate pathway

20-14  Alkaloides

20-15  Carbohydrates

20-16  Secondary metabolites-the building blocks and constitution mechanisms

20.17  Sesquiterpenes

20-18  Diterpenes

20-19  Triterpenes

20.20  Sterol and Steroid Biosynthesis and Metabolism

20.21  Alkaloids

20.22  Carotenoids

20.23  Natural Products as Lead Sources for Drug Development

20.24  Nature as Source of Medicines; Novel Drugs

20.25  The Identification of Bioactive Natural Products

20.26  Natural Products Drug Discovery

20.27  Natural Product-Based Biopesticides for Insect Control

20.28  Natural Products as Sweeteners and Sweetness

20.29  Chemistry of Cosmetics

20.30  Ethnopharmacology and Drug Discovery

20.31  Chinese Traditional Medicine

20.32  Ayurveda in Modern Medicine- Development

20.33  Biologically Active Compounds in Food Products

20.34  Biotransformation of Sesquiterpenoids

20.35  Biotransformation of Di- and Triterpenoids, Steroids,

20.36  Insect Natural Products

20.37  The Natural Products Chemistry of Cyanobacteria

20.38  Natural Product Diversity from Marine Fungi

20.39  Bioactive Metabolites from Marine Dinoflagellates

20.40  Marine Invertebrates- Sponges

20.41  The Natural Products Chemistry of the Gorgonian

20.42  Missasigned Structures-Case Examples from the Past

20.43  Natural Products of Therapeutic Importance

20.44  Natural Products as Probes of Selected Targets

20.45  Terrestrial Plants as a Source of Novel Pharmaceutical

20.46  Marine Macroalgal Natural Products

20.47  Plant Hormones

20.48  Insect Hormones

20.49  Pheromones of Terrestrial Invertebrates

20.50  Pheromones in Vertebrates

20.51  Pheromones of Marine Invertebrates and Algae

20.52  Chemical Defence and Toxins of Plants

20.53  Chemical Defense and Toxins of Lower Terrestrial

20.54  Toxins of Microorganisms

20.55  Terrestrial Natural Products as Antifeedant

20.56  Marine Natural Products as Antifeedants

20.57  Allelochemicals for Plant–Plant and Plant–Microbe

20.58  Allelochemicals in Plant–Insect Interactions

20.59  Human-Environment Interactions-Flavor

20.60  Human–Environment Interactions -Taste

20.61  High Performance Liquid Chromatographic Separation

20.62  Introduction to Macromolecular X-Ray Crystallography

20.63  Characterization by Circular Dichroism Spectroscopy

20.64  Determination of Structure including Absolute

20.65  NMR-Small Molecules and Analysis of Complex

20.66  Biomolecular Recognition by Oligosaccharides

20.67  Determination of Three-Dimensional Structures

20.68  Mass Spectrometry-An Essential Tool for Trace

20.69  Applications of Modern Mass Spectrometry Techniques

20.70  Mass Spectrometry- Structure Determination

20.71  Application of Mass Spectrometry to Rapid Analysis

20.72  Modern Methods for the Isolation of Natural Product

20.73  Natural Products Research and Metabolomics

20.74  New Trends in Alkaloid Isolation and Structure Elucidation

20.75  Guanidine Alkaloids from Marine Invertebrates

20.76  The Chemical Diversity of Bioactive Molecules and Therapeutic Potential of Medicinal Plants

20.77  Bioactive marine natural products

20.78  The drug discovery process

20.79  Mother Nature’s gifts to diseases of man: the impact of natural products on anti-infective, anticholestemics and anticancer drug discovery

20.80  Artifacts and Natural Substances Formed Spontaneously

20.81  Controlled Release of Volatiles under Mild Reaction Conditions: From Nature to Everyday Products

二十一. 天然产物化学家

21.1         Dr. Harborn JB

21.2         Koji Nakanishi’s Enchanting Journey in the World

21.3         Koji Nakanishi Special Issue

21.4         Nakanishi K

21.5         Robert Robinson (I 886-1 975)

21.6         Sir Robert Robinson - His Contribution to Alkaloid Chemistry

21.7         Special Issue for Dr. Wall M

21.8         Special Issue in Honor of Professor David G. I. Kingston

21.9         The History of Molecular Structure Determination Viewed through the Nobel Prizes

21.10     Impossible dreams-E. J. Corey

21.11     The Woodward-Hoffmann Rules

21.12     R.B. Woodward

21.13     Bohlmann bands

21.14     Tribute to Prof. Atta-Ur-Rahman

21.15     K. C. Nicolaou-a personal account

21.16     D. J Faukner-Speciall Issue JNP

21.17     D. John Faulkner

21.18     Dr.Fenical RM

21.19     Paul J. Scheuer

21.20     George Robert Pettit

21.21  Special Issue in Honor of Professor Kenneth L. Rinehart      

21.22  Nakanishi Koji -A Wandering Natural Products Chemist

二十二. 高水平研究论文

22.1 Ivorenolide A, an Unprecedented Immunosuppressive Macrolide from Khaya ivorensis- Structural Elucidation and Bioinspired Total Synthesis

22.2  Glandular Trichomes of Leucosceptrum canum Harbor Defensive Sesterterpenoids

22.3  Bi-linderone, a Highly Modified Methyl-linderone Dimer from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity in Vitro

22.4   A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity

22.5  Paxdaphnidines A and B, Novel Penta- and Tetracyclic Alkaloids from Daphniphyllum paxianum

22.6  Structure-Based Discovery of Potassium Channel Blockers from Natural Products: Virtual Screening and Electrophysiological Assay Testing

22.7  Two Novel Alkaloids with a Unique Fused Hexacyclic Skeleton from Daphniphyllum subverticillatum

22.8  Chloropestolide A, an Antitumor Metabolite with an Unprecedented Spiroketal Skeleton from Pestalotiopsis fici

22.9  Absolute Configuration of New Cytotoxic and Other Bioactive Trichothecene Macrolides

22.10  A New Unusual Natural Pigment from Selaginella sinensis and Its Noticeable Physicochemical Properties

22.11  Lysidicins F-H, Three New Phloroglucinols from Lysidice rhodostegia

22.12  Seco-pregnane steroids target the subgenomic RNA of alphavirus-like RNA viruses

22.13  Chuktabrins A and B, Two Novel Limonoids from the Twigs and Leaves of Chukrasia tabularis   [1]，[2]

22.14  Cipadonoid A, a Novel Limonoid with an Unprecedented Skeleton, from Cipadessa cinerasecns   [1]，[2]

22.15  Codinaeopsin, an Antimalarial Fungal Polyketide   [1]，[2]

22.16  Exiguaquinol A Novel Pentacyclic Hydroquinone from Neopetrosia exigua that Inhibits Helicobacter pylori MurI    [1]，[2]

22.17-NMR  Fumimycin A Peptide Deformylase Inhibitor with an Unusual Skeleton    [1]，[2]

22.18  Abyssomicin E, a Highly Functionalized Polycyclic Metabolite from Streptomyces Species   [1] ，[2]

22.19  Negombins A-I, New Chlorinated Polyfunctional Diterpenoids from the Marine Sponge Negombata Species   [1]，[2]

22.20  Artarborol, a nor-Caryophyllane Sesquiterpene Alcohol from Artemisia arborescens. Stereostructure Assignment through Concurrence of NMR Data and Computational Analysis 1，2

22.21  Nagelamide J, a Novel Dimeric Bromopyrrole Alkaloid from a Sponge Agelas Species   [1] ，[2] 

22.22  Isolation and Characterization of Biogenetically Related Highly Oxygenated Nortriterpenoids from Schisandra chinensis   [1 ]，  [2]

22.23  Cimicifugadine from Cimicifuga foetida, a New Class of Triterpene Alklaoids with Novel Reactivity   [1]，[2] ，  [3]

22.24  Trichodermatides A-D, Novel Polyketides from the Marine-Derived Fungus Trichoderma reesei

22.25  Autophagy-Modulating Aminosteroids Isolated from the Sponge Cliona celata   [1] ， [2]

22.26  Ainsliadimer A, A New Sesquiterpene Lactone Dimer with an Unusual Carbon Skeleton from Ainsliaea macrocephala  

22.27  Amaranzole A, a New N-Imidazolyl Steroid from Phorbas amaranthus

22.28  Bolivianine, a New Sesterpene with an Unusual Skeleton from Hedyosmum angustifolium, and Its Isomer, Isobolivianine

22.29  Chamobtusin A, a Novel Skeleton Diterpenoid Alkaloid from Chamaecyparis obtusa cv. tetragon

22.30  Biogenetical Related Highly Oxygenated Macrocyclic Diterpenes from Sea Spurge Euphorbia paralias

22.31  Latrunculin with a Highly Oxidized Thiazolidinone Ring: Structure Assignment and Actin Docking

22.32  Unique Monoterpenoid Indole Alkaloids from Alstonia scholaris

22.33  Isatisine A, a Novel Alkaloid with an Unprecedented Skeleton from Leaves of Isatis indigotica

22.34  Cassiarins A and B, Novel Antiplasmodial Alkaloids from Cassia siamea

22.35  Calycinumines A and B, Two Novel Alkaloids from Daphniphyllum calycinum    [1]，[2]，[3]

22.36  Ring A Modified Novel Triterpenoids from Dysoxylum hainanense   [1]，[2]

22.37  Trigochilides A and B, Two Highly Modified Daphnane-Type Diterpenoids from Trigonostemon chinensis

22.38  Malyngamide X: The First (7R)-Lyngbic Acid that Connects to a New Tripeptide Backbone from the Thai Sea Hare Bursatella leachii

22.39  Miuraenamides: Antimicrobial Cyclic Depsipeptides Isolated from a Rare and Slightly Halophilic Myxobacterium

22.40  Monoterpenoid Indole Alkaloids Bearing an N4-Iridoid from Gelsemium elegans 

22.41  Absolute Stereochemistry of Amphidinolides G and H

22.42  Isolation of Swinholide A and Related Glycosylated Derivatives from Two Field Collections of Marine Cyanobacteria

22.43  Brevisulcenal-F-A Polycyclic Ether Toxin Associated with Massive Fish-kills in New Zealand

22.44  Prorocentrol, a Polyoxy Linear Carbon Chain Compound Isolated from the Toxic Dinoflagellate Prorocentrum hoffmannianum

22.45  Echinopines A and B-Sesquiterpenoids Possessing an Unprecedented Skeleton from Echinops spinosus

22.46  Cytotoxic C35 Terpenoid Cryptotrione from the Bark of Cryptomeria japonica

22.48  Amphidinolides T2, T3, and T4, New 19-Membered Macrolides from the Dinoflagellate Amphidinium sp. and the Biosynthesis of Amphidinolide T1

22.49  A Biomimetic Transformation of Serratinine into Serratezomine A through a Modified Polonovski Reaction    [1]，[2]

22.50  Absolute Stereochemistry of Amphidinolide C    [1]，[2]

22.51  Absolute Stereochemistry of Amphidinolide E    [1] [2]

22.52  Amphidinolide T, Novel 19-Membered Macrolide from Marine Dinoflagellate Amphidinium sp.    [1] [2]

22.53  Amphidinolide W, a New 12-Membered Macrolide from Dinoflagellate Amphidinium sp.    [1] [2]

22.54  Amphidinolides H2-H5, G2, and G3, New Cytotoxic 26- and 27-Membered Macrolides from Dinoflagellate Amphidinium sp.    [1] [2]

22.55  Celogentins A-C, New Antimitotic Bicyclic Peptides from the Seeds of Celosia argentea      [1]，[2]

22.56  Cephalocyclidin A, a Novel Pentacyclic Alkaloid from Cephalotaxus harringtonia var. nana    [1], [2]

22.57  Colopsinol A, a Novel Polyhydroxyl Metabolite from Marine Dinoflagellate Amphidinium sp.    [1], [2]

22.58  Daphmanidin A, a Novel Hexacyclic Alkaloid from Daphniphyllum teijsmanii    [1], [2]

22.59  Daphnezomines A and B, Novel Alkaloids with an Aza-adamantane Core from Daphniphyllum humile    [1], [2]

22.60  Daphnezomines F and G: Novel Alkaloids with 1-Azabicyclo[ 5.2.2 ]undecane Moiety from Daphniphyllum humile    [1], [2]

22.61  Daphnicyclidins A-H, Novel Hexa- or Pentacyclic Alkaloids from Two Species of Daphniphyllum     [1], [2]

22.62  Daphnicyclidins J and K, Unique Polycyclic Alkaloids from Daphniphyllum humile      [1], [2]

22.63  Daphniglaucins A and B, Novel Polycyclic Quaternary Alkaloids from Daphniphyllum glaucescens      [1], [2]

22.64  Dictyonamides A and B, New Peptides from Marine-Derived Fungus    [1], [2]

22.65  Calyciphyllines A and B, Two Novel Hexacyclic Alkaloids from Daphniphyllum calycinum      [1], [2]

22.66  Lyconadin A, a Novel Alkaloid from Lycopodium complanatum    [1], [2]

22.67  Serratezomines A-C, New Alkaloids from Lycopodium serratum var. serratum     [1], [2]

22.68  Subincanadines A-C, Novel Quaternary Indole Alkaloids from   Aspidosperma subincanum     [1], [2]

22.69  Hodgsonox, a New Class of Sesquiterpene from the Liverwort Lepidolaena hodgsoniae. Isolation Directed by Insecticidal Activity

22.70  Coriatone and Corianlactone, Two Novel Sesquiterpenes from Coriaria nepalensis     [1], [2]

22.71  Bielschowskysin, a Gorgonian-Derived Biologically Active Diterpene with an Unprecedented Carbon Skeleton

22.72  Silvestrol and Episilvestrol, Potential Anticancer Rocaglate Derivatives from Aglaia silvestris    [1], [2]

22.73  Gymnangiamide, a Cytotoxic Pentapeptide from the Marine Hydroid Gymnangium regae     [1], [2]

22.74  Polychlorinated Androstanes from the Burrowing Sponge Cliona nigricans     [1], [2]

22.75  Spiculoic Acids A and B, New Polyketides Isolated from the Caribbean   Marine Sponge Plakortis angulospiculatus    [1], [2]

22.76  Daphmanidins C and D, Novel Pentacyclic Alkaloids from Daphniphyllum teijsmanii    [1], [2]

22.77  Unusual C25 Steroids Produced by a Sponge-Derived Penicillium citrinum

22.78  Cyanthiwigin AC and AD, Two Novel Diterpene Skeletons from the Jamaican Sponge Myrmekioderma styx

22.79  Ceratamines A and B, Antimitotic Heterocyclic Alkaloids Isolated from the Marine Sponge Pseudoceratina sp. Collected in Papua New Guinea      [1], [2]

22.80  Novel Iodinated Diterpenes from a Marine Cyanobacterium and Red Alga Assemblage      [1], [2]

22.81  Sieboldine A, a Novel Tetracyclic Alkaloid from Lycopodium sieboldii, Inhibiting Acetylcholinesterase     [1], [2]

22.82  A New Cytotoxic and Tubulin-Interactive Milnamide Derivative from a Marine Sponge Cymbastela sp.      [1], [2]

22.83  Dioscorealides and Dioscoreanone, Novel Cytotoxic Naphthofuranoxepins, and 1,4-Phenanthraquinone from Dioscorea membranacea Pierre      [1], [2]

22.84  Latonduines A and B, New Alkaloids Isolated from the Marine Sponge Stylissa carteri: Structure Elucidation, Synthesis, and Biogenetic Implications     [1], [2]

22.85  Isolation and Structure of Providencin: A Highly Oxygenated Diterpene Possessing a Unique Bicyclo[ 12.2.0 ]hexadecane Ring System from the Sea Plume Pseudopterogorgia kallos

22.86  Massadine, a Novel Geranylgeranyltransferase Type I Inhibitor from the Marine Sponge Stylissa aff. massa    [1], [2]

22.87  Daphniglaucins A and B, Novel Polycyclic Quaternary Alkaloids from Daphniphyllum glaucescens     [1], [2]

22.88  Micrandilactone A: A Novel Triterpene from Schisandra micrantha     [1], [2]

22.89  TMC-264, a Novel Antiallergic Heptaketide Produced by the Fungus Phoma sp. TC 1674     [1], [2]

22.90  Simplakidine A, a Unique Pyridinium Alkaloid from the Caribbean Sponge Plakortis simplex     [1], [2]

22.91  Novel Antiinsectan Oxalicine Alkaloids from Two Undescribed Fungicolous Penicillium spp.     [1], [2]

22.92  Turrapubesins A and B, First Examples of Halogenated and Maleimide-Bearing Limonoids in Nature from Turraea pubescens     [1], [2]

22.93  Chukvelutins A-C, 16-Norphragmalin Limonoids with Unprecedented Skeletons from Chukrasia tabularis var. velutina     [1]

22.94  UCS 1025A and B, New Antitumor Antibiotics from the Fungus Acremonium Species     [1], [2]

22.95  Diterpenoids from Cultured Erythropodium caribaeorum     [1], [2]

22.96  Caminoside A, an Antimicrobial Glycolipid Isolated from the Marine Sponge Caminus sphaeroconia     [1], [2]

22.97  Application of High-Field NMR and Cryogenic Probe Technologies in the Structural Elucidation of Poecillastrin A, a New Antitumor Macrolide Lactam from the Sponge Poecillastra Species     [1], [2]

22.98  Stereostructure of a Novel Cytotoxic 18-Membered Macrolactone Antibiotic FD-891   

22.99  Thiersinines A and B: Novel Antiinsectan Indole Diterpenoids from a New Fungicolous Penicillium Species (NRRL 28147)     [1], [2]

22.100 Azaspirene: A Novel Angiogenesis Inhibitor Containing a 1-Oxa-7-azaspiro[4.4]non-2-ene-4,6-dione Skeleton Produced by the Fungus Neosartorya sp.     

22.101  Geometry and Halogen Regiochemistry Determination of Vicinal Vinyl Dihalides by ¹H and ¹³C NMR. Application to the Structure Elucidation of Prefuroplocamioid, an Unusual Marine Monoterpene     [1], [2]

22.102  A Novel Cyclodepsipeptide, HA23, from a Fusarium sp.     [1], [2]

22.103  Caylobolide A, a Unique 36-Membered Macrolactone from a Bahamian Lyngbya majuscule  

22.104  Aspergilloxide, A Novel Sesterterpene Epoxide from a Marine-Derived Fungus of the Genus Aspergillus     [1], [2]

22.105  Structure, Stereochemistry, and Biological Activity of Integramycin, a Novel Hexacyclic Natural Product Produced by Actinoplanes sp. That Inhibits HIV-1 Integrase     [1], [2]

22.106  Akanthomycin, a New Antibiotic Pyridone from the Entomopathogenic Fungus Akanthomyces gracilis     [1], [2]

22.107  Militarinone A, a Neurotrophic Pyridone Alkaloid from Paecilomyces militaris1     [1], [2]

22.108  The First Naturally Occurring Tie2 Kinase Inhibitor   

22.109  Paesslerins A and B: Novel Tricyclic Sesquiterpenoids from the Soft Coral Alcyonium paessleri   

22.110  Isolation, Structure Determination, and Synthesis of Neodysiherbaine A, a New Excitatory Amino Acid from a Marine Sponge     [1], [2]

22.111  The First Atisane Diterpenoids from a Liverwort: Polyols from Lepidolaena clavigera     [1], [2]

22.112  The Ajudazols A and B, Novel Isochromanones from Chondromyces crocatus (Myxobacteria)- Isolation and Structure Elucidation

22.113  Eight-Membered Cyclic 1,2,3-Trithiocane Derivatives from Perophora viridis, an Atlantic Tunicate

22.114  Potamopholide, a New Sesquiterpene Lactone From Vernonia potamophila

22.115  Luotonin A. A Naturally Occurring Human DNA Topoisomerase I Poison

22.116  Paxdaphnidines A and B, Novel Penta- and Tetracyclic Alkaloids from Daphniphyllum paxianum

22.117  First Diamino Daphniphyllum Alkaloid, Daphnipaxinin, with an Unprecedented Heterohexacyclic Skeleton from Daphniphyllum paxianum

22.118  Turrapubesins A and B, First Examples of Halogenated and Maleimide-Bearing Limonoids in Nature from Turraea pubescens     [1], [2]

22.119  Xylogranatins A-D: Novel Tetranortriterpenoids with an Unusual 9,10-seco Scaffold from Marine Mangrove Xylocarpus granatum

22.120  The First Limonoid Peroxide in the Meliaceae Family-Walsuronoid A from Walsura robusta

22.121  Chlorahololides A and B, Two Potent and Selective Blockers of the Potassium Channel Isolated from Chloranthus holostegius

22.122  Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonicaw

22.123  Immunosuppressive Polyketides from Mantis-Associated Daldinia eschscholzii

22.124  Trigochilides A and B, Two Highly Modified Daphnane-Type Diterpenoids from Trigonostemon chinensis

22.125  Structure Determination of Grandifotane A from Khaya grandifoliola by NMR, X-ray Diffraction, and ECD Calculation

22.126  Trigochinins A-C: Three New Daphnane-Type Diterpenes from Trigonostemon chinensis

22. 127  Aphanamolide A, a New Limonoid from Aphanamixis polystachya

22. 128  Synthesis and Assignment of the Absolute Configuration of Indenotryptoline Bisindole Alkaloid BE-54017

22. 129  Walsucochinoids A and B: New Rearranged Limonoids from Walsura cochinchinensis

22. 130 Serratustones A and B Representing a New Dimerization Pattern of Two Types of Sesquiterpenoids from Chloranthus serratus

22. 131 Chukrasones A and B: Potential Kv1.2 Potassium Channel Blockers with New Skeletons from Chukrasia tabularis

22. 132  Fluevirosines A-C: A Biogenesis Inspired Example in the Discovery of New Bioactive Scaffolds from Flueggea virosa

22.133  Daphcalycine, a Novel Heptacycle Fused Ring System Alkaloid from Daphniphyllum calycinum

22.134  Two Novel Alkaloids with a Unique Fused Hexacyclic Skeleton from Daphniphyllum subverticillatum

22.135  Paxdaphnidines A and B, Novel Penta- and Tetracyclic Alkaloids from Daphniphyllum paxianum

22.136  Compound Representatives of a New ype of Triterpenoid from Aglaia dorata 

22.137  Two Novel Tetrairidoid Glucosides from Dipsacus asper

22.138  Lathyranone A: A Diterpenoid Possessing an Unprecedented Skeletonfrom Euphorbia lathyris

22.139  Structure Elucidation and Biomimetic Synthesis of Hostasinine A, a New Benzylphenethylamine Alkaloid from Hosta plantaginea

22.140  Daphhimalenine A, a New Alkaloid withan Unprecedented Skeleton, from Daphniphyllum himalense

22.141  Three New Indole Alkaloids from Trigonostemon lii

22.142  Scaparvin A, A Novel Cagedcis-Clerodane with an Unprecedented C-6/C-11 Bond, and Related Diterpenoids from the Liverwort Scapania parva

22.143  A [2 + 2] Cycloaddition Dimer and a Diels_Alder Adduct from Alpinia katsumadai

22.144  Pallambins A and B, Unprecedented Hexacyclic 19-nor-Secolabdane Diterpenoids from the Chinese Liverwort Pallavicinia ambigua

22.145  Lycojaponicumins A-C, Three Alkaloidswith an Unprecedented Skeleton fromLycopodium japonicum

22.146  Interconversion of the Pallambins through Photoinduced Rearrangement

22.147  Lycojaponicumins D and E: Two New Alkaloids from Lycopodium japonicum

22.148  Novel Phloroglucinol Derivatives from the Roots of Lysidice rhodostegia

22.149  Lysidicins F-H, Three New Phloroglucinols from Lysidice rhodostegia

22.150  Daphnicyclidins A-H, Novel Hexa- or Pentacyclic Alkaloids from Two Species of Daphniphyllum

22.151  Epoxyquinol A, a Highly Functionalized Pentaketide Dimer with Antiangiogenic Activity Isolated from Fungal Metabolites

22.152  Exiguamine A, an Indoleamine-2,3-dioxygenase (IDO) Inhibitor Isolated from the Marine Sponge Neopetrosia exigua

22.153  Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine Cyanobacterium Leptolyngbya sp.

22.154  Structure and Absolute Configuration of Karlotoxin-2, an Ichthyotoxin from the Marine Dinoflagellate Karlodinium veneficum

22.155  Brevisulcenal-F: A Polycyclic Ether Toxin Associated with Massive Fish-kills in New Zealand

22.156  Iriomoteolide -3a , a Cytotoxic 15-Membered Macrolide from a Marine Dinoflagellate Amphidinium Species

22.157  Structure and Stereochemistry of a New Cytotoxic Polychlorinated Sulfolipid from Adriatic Shellfish

22.1 58  Isolation, Structure, and Absolute Stereochemistry of Platensimycin, A Broad Spectrum Antibiotic Discovered Using an Antisense Differential Sensitivity Strateg

22. 159 Structure and Activity of Largazole, a Potent Antiproliferative Agent from the Floridian Marine Cyanobacterium Symploca sp.

22.160  Hirsutane-Type Sesquiterpenes with Uncommon Modifications from Three Basidiomycetes

22.161  Nigricanosides A and B, Antimitotic Glycolipids Isolated from the Green Alga Avrainvillea nigricans Collected in Dominica

22.162  New Hemiketal Steroid from the Soft Coral Cladiella sp.